Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Current Medicinal Chemistry Page 1 Current Medicinal Chemistry Current Medicinal
Chemistry ISSN: 0929-8673 eISSN: 1875-533X The International Journal for Timely In-depth …

Bidirectional communication links operate between the brain and the body. Afferent immune-
to-brain signals are capable of inducing changes in mood and behavior. Chronic heavy …

Mounting evidence that alterations in brain-derived neurotrophic factor (BDNF) levels and
signaling may be involved in the etiopathogenesis of Alzheimer's disease (AD) has …

The nerve growth factor (NGF) belongs to the family of neurotrophic factors. Initially
discovered as a signaling molecule involved in the survival, protection, differentiation, and …

Alcohol use disorder (AUD) is a chronic, relapsing brain disorder, characterized by
compulsive alcohol seeking and disrupted brain function. In individuals with AUD …

In this study, we evaluated, in the mouse, the effects of 20 mg/kg ip daily administration for
15 consecutive days of a blend of polyphenols, containing mostly oleuropein, extracted from …

Preclinical study results suggest that brain-derived neurotrophic factor (BDNF) and glial cell
line-derived neurotrophic factor (GDNF) modulate addictive behaviour. Therefore we …

Neurotrophic growth factors were originally characterized for their support in neuronal
differentiation, outgrowth, and survival during development. However, it has been …

Chronic exposure to opiates impairs spatial learning and memory. Given the well-known
beneficial effects of voluntary exercise on cognitive functions, we investigated whether …