Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023 - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

[HTML][HTML] Sulfoxides in medicine

E Wojaczyńska, J Wojaczyński - Current Opinion in Chemical Biology, 2023 - Elsevier
In the review, current status of sulfoxides on the pharmaceutical market is discussed. In the
first part of the article, natural sulfoxides will be described with a special focus on …

Advances in polyhydroxyalkanoate nanocarriers for effective drug delivery: An overview and challenges

P Prakash, WH Lee, CY Loo, HSJ Wong… - Nanomaterials, 2022 - mdpi.com
Polyhydroxyalkanoates (PHAs) are natural polymers produced under specific conditions by
certain organisms, primarily bacteria, as a source of energy. These up-and-coming …

Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (Mpro) and Papain-like Protease (PLpro)

FB Omage, A Madabeni, AR Tucci… - Journal of Chemical …, 2023 - ACS Publications
The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …

High-throughput single cell metabolomics and cellular heterogeneity exploration by inertial microfluidics coupled with pulsed electric field-induced electrospray …

D Feng, H Li, T Xu, F Zheng, C Hu, X Shi, G Xu - Analytica Chimica Acta, 2022 - Elsevier
Single cell metabolomics can obtain the metabolic profiles of individual cells and reveal
cellular heterogeneity. However, high-throughput single-cell mass spectrometry (MS) …

Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: Preparation and in vitro characterization

YW Wu, DY Lee, YL Lu, L Delila, O Nebie, L Barro… - Platelets, 2023 - Taylor & Francis
Platelet extracellular vesicles (PEVs) are an emerging delivery vehi for anticancer drugs due
to their ability to target and remain in the tumor microenvironment. However, there is still a …

Kaempferol and fisetin-related signaling pathways induce apoptosis in head and neck cancer cells

R Kubina, K Krzykawski, A Dziedzic, A Kabała-Dzik - Cells, 2023 - mdpi.com
Despite the relative effectiveness of standard cancer treatment strategies, head and neck
cancer (HNC) is still considered one of the leading causes of mortality and morbidity. While …

Aurones: a promising scaffold to inhibit SARS-CoV-2 replication

GS Caleffi, AS Rosa, LG de Souza… - Journal of Natural …, 2023 - ACS Publications
Aurones are a small subgroup of flavonoids in which the basic C6–C3–C6 skeleton is
arranged as (Z)-2-benzylidenebenzofuran-3 (2 H)-one. These compounds are structural …

Prodigiosin/celecoxib-loaded into zein/sodium caseinate nanoparticles as a potential therapy for triple negative breast cancer

WA Mohamed, NA El-Nekhily, HE Mahmoud… - Scientific Reports, 2024 - nature.com
Nowadays, breast cancer is considered one of the most upsetting malignancies among
females. Encapsulation of celecoxib (CXB) and prodigiosin (PDG) into zein/sodium …

HMG-CoA reductase degrader, SR-12813, counteracts statin-induced upregulation of HMG-CoA reductase and augments the anticancer effect of atorvastatin

Y Zhou, J Tashiro, S Kamatani, N Irie, A Suzuki… - Biochemical and …, 2023 - Elsevier
Statins are cholesterol-lowering drugs that have exhibited potential as cancer therapeutic
agents. However, as some cancer cells are resistant to statins, broadening an anticancer …