Design principles of microneedles for drug delivery and sampling applications
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …
bioactive molecules for local or systemic therapies attributing to their minimally invasive …
[HTML][HTML] Sulfoxides in medicine
E Wojaczyńska, J Wojaczyński - Current Opinion in Chemical Biology, 2023 - Elsevier
In the review, current status of sulfoxides on the pharmaceutical market is discussed. In the
first part of the article, natural sulfoxides will be described with a special focus on …
first part of the article, natural sulfoxides will be described with a special focus on …
Advances in polyhydroxyalkanoate nanocarriers for effective drug delivery: An overview and challenges
Polyhydroxyalkanoates (PHAs) are natural polymers produced under specific conditions by
certain organisms, primarily bacteria, as a source of energy. These up-and-coming …
certain organisms, primarily bacteria, as a source of energy. These up-and-coming …
Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (Mpro) and Papain-like Protease (PLpro)
FB Omage, A Madabeni, AR Tucci… - Journal of Chemical …, 2023 - ACS Publications
The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …
High-throughput single cell metabolomics and cellular heterogeneity exploration by inertial microfluidics coupled with pulsed electric field-induced electrospray …
Single cell metabolomics can obtain the metabolic profiles of individual cells and reveal
cellular heterogeneity. However, high-throughput single-cell mass spectrometry (MS) …
cellular heterogeneity. However, high-throughput single-cell mass spectrometry (MS) …
Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: Preparation and in vitro characterization
YW Wu, DY Lee, YL Lu, L Delila, O Nebie, L Barro… - Platelets, 2023 - Taylor & Francis
Platelet extracellular vesicles (PEVs) are an emerging delivery vehi for anticancer drugs due
to their ability to target and remain in the tumor microenvironment. However, there is still a …
to their ability to target and remain in the tumor microenvironment. However, there is still a …
Kaempferol and fisetin-related signaling pathways induce apoptosis in head and neck cancer cells
Despite the relative effectiveness of standard cancer treatment strategies, head and neck
cancer (HNC) is still considered one of the leading causes of mortality and morbidity. While …
cancer (HNC) is still considered one of the leading causes of mortality and morbidity. While …
Aurones: a promising scaffold to inhibit SARS-CoV-2 replication
GS Caleffi, AS Rosa, LG de Souza… - Journal of Natural …, 2023 - ACS Publications
Aurones are a small subgroup of flavonoids in which the basic C6–C3–C6 skeleton is
arranged as (Z)-2-benzylidenebenzofuran-3 (2 H)-one. These compounds are structural …
arranged as (Z)-2-benzylidenebenzofuran-3 (2 H)-one. These compounds are structural …
Prodigiosin/celecoxib-loaded into zein/sodium caseinate nanoparticles as a potential therapy for triple negative breast cancer
WA Mohamed, NA El-Nekhily, HE Mahmoud… - Scientific Reports, 2024 - nature.com
Nowadays, breast cancer is considered one of the most upsetting malignancies among
females. Encapsulation of celecoxib (CXB) and prodigiosin (PDG) into zein/sodium …
females. Encapsulation of celecoxib (CXB) and prodigiosin (PDG) into zein/sodium …
HMG-CoA reductase degrader, SR-12813, counteracts statin-induced upregulation of HMG-CoA reductase and augments the anticancer effect of atorvastatin
Y Zhou, J Tashiro, S Kamatani, N Irie, A Suzuki… - Biochemical and …, 2023 - Elsevier
Statins are cholesterol-lowering drugs that have exhibited potential as cancer therapeutic
agents. However, as some cancer cells are resistant to statins, broadening an anticancer …
agents. However, as some cancer cells are resistant to statins, broadening an anticancer …