Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …

Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate
metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase …

Calcium (Ca2+) and phosphate (PO43−) homeostasis are coordinated by systemic and local
factors that regulate intestinal absorption, influx and efflux from bone, and kidney excretion …

In contrast to the regulation of calcium homeostasis, which has been extensively studied
over the past several decades, relatively little is known about the regulation of phosphate …

Fibroblast growth factor (FGF) 23 is a phosphaturic hormone whose physiologic actions on
target tissues are mediated by FGF receptors (FGFR) and klotho, which functions as a co …

Premature aging is a process associated with a progressive accumulation of deleterious
changes over time, an impairment of physiologic functions, and an increase in the risk of …

Mineral and bone metabolism are regulated differently in utero compared with the adult. The
fetal kidneys, intestines, and skeleton are not dominant sources of mineral supply for the …

Given the dramatic increase in skeletal size during growth, the need to preserve skeletal
mass during adulthood, and the large capacity of bone to store calcium and phosphate …

Osteocytes are differentiated osteoblasts that become surrounded by matrix during the
process of bone formation. Acquisition of the osteocyte phenotype is achieved by profound …

Mice with constitutive activation of parathyroid hormone (PTH) receptor signaling in
osteocytes (DMP1-caPTHR1 transgenic mice) exhibit increased bone mass and remodeling …