Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Aging is the greatest risk factor for nearly all major chronic diseases, including
cardiovascular diseases, cancer, Alzheimer's and other neurodegenerative diseases of …

Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

The biological cycles of milk production and reproduction determine dairying profitability
thus making management decisions dynamic and time-dependent. Diseases also negatively …

Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we
will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its …

Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that
oxidative stress and molecular inflammation play important roles in age-related muscle …

Major depressive disorder (MDD) is a heterogeneous illness for which there are currently no
effective methods to objectively assess severity, endophenotypes, or response to treatment …

Opa1 participates in inner mitochondrial membrane fusion and cristae morphogenesis.
Here, we show that muscle‐specific Opa1 ablation causes reduced muscle fiber size …

Aging of the immune system in humans and animals is characterized by a decline in both
adaptive and innate immune responses. Paradoxically, aging is also associated with a state …

Insulin-like growth factor-I (IGF-I) is closely related to insulin but has distinct metabolic
actions. IGF-I is an important stimulant of protein synthesis in muscle, but it also stimulates …