Protein misfolding, aggregation and mechanism of amyloid cytotoxicity: An overview and therapeutic strategies to inhibit aggregation

M Zaman, AN Khan, SM Zakariya, RH Khan - International journal of …, 2019 - Elsevier
Protein and peptides are converted from their soluble forms into highly ordered fibrillar
aggregates under various conditions inside the cell. Such transitions confer diverse …

[HTML][HTML] Cold atmospheric plasma induces the curing mechanism of diabetic wounds by regulating the oxidative stress mediators iNOS and NO, the pyroptotic …

G Badr, FM El-Hossary, FEM Lasheen, NZ Negm… - Biomedicine & …, 2023 - Elsevier
It has been demonstrated that cold atmospheric plasma (CAP) accelerates the wound
healing process, however the underlying molecular pathways behind this effect remain …

An insight into the interaction between Indisulam and human serum albumin: Spectroscopic method, computer simulation and in vitro cytotoxicity assay

B Zhou, H Zhou, L Xu, R Cai, C Chen, B Chi, X Tuo - Bioorganic Chemistry, 2022 - Elsevier
Indisulam (IDM) is a sulfanilamide anticancer agent and has been identified as a molecular
glue recently. It shows potential for novel therapies development and brings more hope for …

A comprehensive spectroscopic and computational investigation to probe the interaction of antineoplastic drug nordihydroguaiaretic acid with serum albumins

S Nusrat, MK Siddiqi, M Zaman, N Zaidi, MR Ajmal… - PLoS …, 2016 - journals.plos.org
Exogenous drugs that are used as antidote against chemotheray, inflammation or viral
infection, gets absorbed and interacts reversibly to the major serum transport protein ie …

Biophysical insight into the anti-amyloidogenic behavior of taurine

SK Chaturvedi, P Alam, JM Khan, MK Siddiqui… - International journal of …, 2015 - Elsevier
In this work, we investigated the inhibitory ability of taurine on the aggregation of Human
serum albumin (HSA) and also examined how it controls the kinetic parameters of the …

Unraveling comparative anti-amyloidogenic behavior of pyrazinamide and D-cycloserine: a mechanistic biophysical insight

SK Chaturvedi, N Zaidi, P Alam, JM Khan, A Qadeer… - PloS one, 2015 - journals.plos.org
Amyloid fibril formation by proteins leads to variety of degenerative disorders called
amyloidosis. While these disorders are topic of extensive research, effective treatments are …

Different conformational states of hen egg white lysozyme formed by exposure to the surfactant of sodium dodecyl benzenesulfonate

JM Khan, A Malik, P Sen, A Ahmed, M Ahmed… - International journal of …, 2019 - Elsevier
The aim of this study was to investigate the effects of sodium dodecyl benzenesulfonate
(SDBS) on hen egg white lysozyme (HEWL) fibrillogenesis at pH 7.4. HEWL fibrillogenesis …

Unveiling the stimulatory effects of tartrazine on human and bovine serum albumin fibrillogenesis: Spectroscopic and microscopic study

NA Al-Shabib, JM Khan, MA Alsenaidy… - Spectrochimica acta part …, 2018 - Elsevier
Amyloid fibrils are playing key role in the pathogenesis of various neurodegenerative
diseases. Generally anionic molecules are known to induce amyloid fibril in several …

Exploring the effect of choline-based ionic liquids on the stability and activity of stem bromelain

PK Kumar, M Bisht, P Venkatesu… - The Journal of …, 2018 - ACS Publications
Enzymes are very important components which are vital for the existence of every cellular
life. There is significant interest in the use of structurally stable and catalytically active …

Unraveling the molecular mechanism of the effects of sodium dodecyl sulfate, salts, and sugars on amyloid fibril formation in camel IgG

MA Ismael, JM Khan, A Malik, MA Alsenaidy… - Colloids and Surfaces B …, 2018 - Elsevier
Sodium dodecyl sulfate (SDS) is an anionic surfactant that can be used to stimulate protein
fibrillation in vitro. Here, we investigated the effects of SDS on camel IgG aggregation at pH …