The prevalence and incidence of NAFLD worldwide: a systematic review and meta-analysis

K Riazi, H Azhari, JH Charette… - The lancet …, 2022 - thelancet.com
Background Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease
worldwide and the leading cause of liver-related morbidity and mortality. We aimed to …

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

D Ferguson, BN Finck - Nature Reviews Endocrinology, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease
in the world, yet there are still no approved pharmacological therapies to prevent or treat this …

Sex and gender: modifiers of health, disease, and medicine

F Mauvais-Jarvis, NB Merz, PJ Barnes, RD Brinton… - The Lancet, 2020 - thelancet.com
Clinicians can encounter sex and gender disparities in diagnostic and therapeutic
responses. These disparities are noted in epidemiology, pathophysiology, clinical …

A researcher's guide to preclinical mouse NASH models

S Gallage, JEB Avila, P Ramadori, E Focaccia… - Nature …, 2022 - nature.com
Non-alcoholic fatty liver disease (NAFLD) and its inflammatory form, non-alcoholic
steatohepatitis (NASH), have quickly risen to become the most prevalent chronic liver …

[HTML][HTML] Sex differences in metabolic regulation and diabetes susceptibility

B Tramunt, S Smati, N Grandgeorge, F Lenfant… - Diabetologia, 2020 - Springer
Gender and biological sex impact the pathogenesis of numerous diseases, including
metabolic disorders such as diabetes. In most parts of the world, diabetes is more prevalent …

Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: an updated meta-analysis of 501 022 adult individuals

A Mantovani, G Petracca, G Beatrice, H Tilg, CD Byrne… - Gut, 2021 - gut.bmj.com
Objective Follow-up studies have shown that non-alcoholic fatty liver disease (NAFLD) is
associated with an increased risk of incident diabetes, but currently, it is uncertain whether …

MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease

M Eslam, AJ Sanyal, J George, A Sanyal… - Gastroenterology, 2020 - Elsevier
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the
population, and has no approved drug therapy. Although pharmacotherapies are in …

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

G Targher, CD Byrne, H Tilg - Gut, 2020 - gut.bmj.com
Non-alcoholic fatty liver disease (NAFLD) is a public health problem, affecting up to a third of
the world's adult population. Several cohort studies have consistently documented that …

NAFLD and NASH in postmenopausal women: implications for diagnosis and treatment

JK DiStefano - Endocrinology, 2020 - academic.oup.com
Nonalcoholic fatty liver disease (NAFLD) prevalence in women is increasing worldwide.
Women of reproductive age have lower rates of NAFLD compared with men; however, this …

[PDF][PDF] Pathogenesis of nonalcoholic steatohepatitis: an overview

G Parthasarathy, X Revelo… - Hepatology …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous group of liver diseases
characterized by the accumulation of fat in the liver. The heterogeneity of NAFLD is reflected …