Crown ethers are heterocycles that, in their simplest form, are cyclic oligomers of dioxane.
The essential repeating unit of any simple crown ether is ethyleneoxy, ie,-CH2CH2O-, which …

In this Account, we describe the development of several diverse families of synthetic,
membrane-active amphiphiles that form pores and facilitate transport within membrane …

Despite the great interest in artificial ion channel design, only a small number of channel-
forming molecules are currently available for addressing challenging problems, particularly …

This critical review covers synthetic ion channels and pores created between January 2004
and December 2005 comprehensively. The discussion of a rich collection of structural motifs …

Several life‐threatening diseases, also known as 'Channelopathies' are linked to
irregularities in ion transport proteins. Significant research efforts have fostered the …

The control of ion transport and homeostasis is a critical function of living organisms. In this
perspective, an overview of different synthetic systems capable of facilitating the …

Crown ethers are of enormous interest and importance in chemistry, biochemistry, materials
science, catalysis, separation, transport and encapsulated processes, as well as in the …

The compelling chemical goal of modeling protein channel behavior has led to synthetic
compounds that are true ion channels. Although they largely lack the selectivity and …

Cell death is a fundamental biological process that is present in numerous disease
pathologies. Fluorescent probes that detect cell death have been developed for a myriad of …

The present paper demonstrates the antiproliferative ability and structure− activity
relationships (SAR) of 14 crown and aza-crown ether analogues on five tumor-cell types …