T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …

DNA damage-induced signaling by ATR and CHK1 inhibits DNA replication, stabilizes
stalled and collapsed replication forks, and mediates the repair of multiple classes of DNA …

Phosphorylation is a form of protein posttranslational modification (PTM) that regulates many
biological processes. Whereas phosphoproteomics is a scientific discipline that identifies …

Protein glycosylation and phosphorylation are two important protein post-translational
modifications. Mass spectrometry (MS) has been proved to be a powerful technique in …

Because of the low stoichiometry of protein phosphorylation, targeted enrichment prior to LC–
MS/MS analysis is still essential. The trend in phosphoproteome analysis is shifting toward …

IKAROS is a master regulator of cell fate determination in lymphoid and other hematopoietic
cells. This transcription factor orchestrates the association of epigenetic regulators with …

Endosomal signaling downstream of G-protein-coupled receptors (GPCRs) has emerged as
a novel paradigm with important pharmacological and physiological implications. However …

Protein kinase A (PKA) is a ubiquitous, promiscuous kinase whose activity is specified
through subcellular localization mediated by A-kinase anchoring proteins (AKAPs). PKA has …

T Lymphocyte activation involves a substantial reorganization of the membranous and
intracellular compartments. Signaling complexes assemble and dismantle in a highly …