Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …

Background Glaucoma, the leading cause of irreversible blindness worldwide, is a type of
retinal disease characterized by the selective death of retinal ganglion cells (RGCs) …

Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that
has been associated with several types of cancer. However, its biological significance, as …

Cell migration is a key process in cancer metastasis, allowing malignant cells to spread from
the primary tumor to distant organs. At the molecular level, migration is the result of several …

Aqueous humor drainage from the anterior eye determines intraocular pressure (IOP) under
homeostatic and pathological conditions. Swelling of the trabecular meshwork (TM) alters its …

Key points Trabecular meshwork (TM) is a highly mechanosensitive tissue in the eye that
regulates intraocular pressure through the control of aqueous humour drainage. Its …

Transient receptor potential vanilloid 4 (TRPV4) is a non-selective mechanosensitive ion
channel expressed by various macrophage populations. Recent reports have characterized …

The physiological and neurological correlates of plummeting brain osmolality during edema,
traumatic CNS injury, and severe ischemia are compounded by neuroinflammation. Using …