Brain insulin signalling in metabolic homeostasis and disease
T Scherer, K Sakamoto, C Buettner - Nature Reviews Endocrinology, 2021 - nature.com
Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …
Insulin action in brain regulates systemic metabolism and brain function
Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …
The melanocortin pathway and control of appetite-progress and therapeutic implications
G Baldini, KD Phelan - Journal of Endocrinology, 2019 - joe.bioscientifica.com
The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
A Kleinridders, W Cai, L Cappellucci… - Proceedings of the …, 2015 - National Acad Sciences
Diabetes and insulin resistance are associated with altered brain imaging, depression, and
increased rates of age-related cognitive impairment. Here we demonstrate that mice with a …
increased rates of age-related cognitive impairment. Here we demonstrate that mice with a …
The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry
ME Hess, S Hess, KD Meyer, LAW Verhagen… - Nature …, 2013 - nature.com
Dopaminergic (DA) signaling governs the control of complex behaviors, and its deregulation
has been implicated in a wide range of diseases. Here we demonstrate that inactivation of …
has been implicated in a wide range of diseases. Here we demonstrate that inactivation of …
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
K Timper, JC Brüning - Disease models & mechanisms, 2017 - journals.biologists.com
The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …
for a better understanding of the underlying causes of increased weight gain and its …
Central neural regulation of brown adipose tissue thermogenesis and energy expenditure
Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic
function of brown adipose tissue (BAT) and contributes to the maintenance of body …
function of brown adipose tissue (BAT) and contributes to the maintenance of body …
Acute and long-term suppression of feeding behavior by POMC neurons in the brainstem and hypothalamus, respectively
POMC-derived melanocortins inhibit food intake. In the adult rodent brain, POMC-
expressing neurons are located in the arcuate nucleus (ARC) and the nucleus tractus …
expressing neurons are located in the arcuate nucleus (ARC) and the nucleus tractus …
IL-6 improves energy and glucose homeostasis in obesity via enhanced central IL-6 trans-signaling
K Timper, JL Denson, SM Steculorum, C Heilinger… - Cell reports, 2017 - cell.com
Summary Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find
that central application of IL-6 in mice suppresses feeding and improves glucose tolerance …
that central application of IL-6 in mice suppresses feeding and improves glucose tolerance …