Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease

F Violi, V Cammisotto, S Bartimoccia… - Nature reviews …, 2023 - nature.com
Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

Cell type-specific roles of NF-κB linking inflammation and thrombosis

M Mussbacher, M Salzmann, C Brostjan… - Frontiers in …, 2019 - frontiersin.org
The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review

F Di Vincenzo, A Del Gaudio, V Petito… - Internal and emergency …, 2024 - Springer
The intestine is the largest interface between the internal body and the external
environment. The intestinal barrier is a dynamic system influenced by the composition of the …

Current knowledge and management of portal vein thrombosis in cirrhosis

M Senzolo, G Garcia-Tsao, JC García-Pagán - Journal of hepatology, 2021 - Elsevier
Portal vein thrombosis (PVT) is an increasingly recognised complication of cirrhosis whose
incidence increases in parallel with the severity of cirrhosis. Several risk factors have been …

Endothelial dysfunction in obesity-induced inflammation: molecular mechanisms and clinical implications

IK Kwaifa, H Bahari, YK Yong, SM Noor - Biomolecules, 2020 - mdpi.com
Obesity is characterized by the excessive deposition of fat that may interfere with the normal
metabolic process of the body. It is a chronic condition associated with various metabolic …

Diagnosis, development, and treatment of portal vein thrombosis in patients with and without cirrhosis

NM Intagliata, SH Caldwell, A Tripodi - Gastroenterology, 2019 - Elsevier
Portal vein thrombosis unrelated to solid malignancy is common in patients with cirrhosis,
but less frequently observed in patients without cirrhosis. Prompt diagnosis and …

[HTML][HTML] Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation

A Nicoletti, FR Ponziani, M Biolato… - World journal of …, 2019 - ncbi.nlm.nih.gov
The intimate connection and the strict mutual cooperation between the gut and the liver
realizes a functional entity called gut-liver axis. The integrity of intestinal barrier is crucial for …

The pathophysiology of portal vein thrombosis in cirrhosis: getting deeper into Virchow's triad

A Anton, G Campreciós, V Pérez-Campuzano… - Journal of Clinical …, 2022 - mdpi.com
Portal vein thrombosis (PVT) is a common complication among patients with cirrhosis.
However, its pathophysiology is not well established and there are currently very few …

Non-coding RNA: role in gestational diabetes pathophysiology and complications

T Filardi, G Catanzaro, S Mardente, A Zicari… - International Journal of …, 2020 - mdpi.com
Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the
second or third trimester of pregnancy. GDM can lead to short-term and long-term …

Gut dysbiosis, endotoxemia and clotting activation: a dangerous trio for portal vein thrombosis in cirrhosis

F Violi, P Pignatelli, V Castellani, R Carnevale… - Blood reviews, 2023 - Elsevier
Liver cirrhosis (LC) is associated with portal venous thrombosis (PVT) in roughly 20% of
cirrhotic patients but the underlying mechanism is still unclear. Low-grade endotoxemia by …