Transcriptional regulation is essential for the correct functioning of cells during development
and in postnatal life. The basic Helix-loop-Helix (bHLH) superfamily of transcription factors is …

Depression is a complex, heterogeneous disorder and a leading contributor to the global
burden of disease. Most previous research has focused on individual brain regions and …

The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that
organizes and stabilizes synaptic receptors, ion channels, structural proteins, and signaling …

Motor and sensory functions of the spinal cord are mediated by populations of cardinal
neurons arising from separate progenitor lineages. However, each cardinal class is …

Establishment of long-range fiber tracts by neocortical projection neurons is fundamental for
higher brain functions. The molecular control of axon tract formation, however, is still poorly …

While the transcription factor NEUROD2 has recently been associated with epilepsy, its
precise role during nervous system development remains unclear. Using a multi-scale …

The neurotransmitter GABA and its receptors assume essential functions during fetal and
postnatal brain development. The last trimester of a human pregnancy and early postnatal …

Abstract FOXP1, FOXP2, and FOXP4 are three members of the FOXP gene subfamily of
transcription factors involved in the development of the central nervous system. Previous …

Synaptic target specificity, whereby neurons make distinct types of synapses with different
target cells, is critical for brain function, yet the mechanisms driving it are poorly understood …

Brain-derived neurotrophic factor (BDNF) controls the survival, growth, and function of
neurons both during the development and in the adult nervous system. Bdnf is transcribed …