Novel HER2-targeting antibody-drug conjugates of trastuzumab beyond T-DM1 in breast cancer: trastuzumab deruxtecan (DS-8201a) and (Vic-) trastuzumab …
Z Xu, D Guo, Z Jiang, R Tong, P Jiang, L Bai… - European journal of …, 2019 - Elsevier
Targeted drug delivery has improved cancer treatment significantly in recent years, although
it is difficult to achieve. Different approaches have been developed to apply targeted drug …
it is difficult to achieve. Different approaches have been developed to apply targeted drug …
Quantification of tumor heterogeneity: from data acquisition to metric generation
Tumors are unique and complex ecosystems, in which heterogeneous cell subpopulations
with variable molecular profiles, aggressiveness, and proliferation potential coexist and …
with variable molecular profiles, aggressiveness, and proliferation potential coexist and …
[HTML][HTML] Osimertinib in Resected EGFR-Mutated Non–Small-Cell Lung Cancer
Background Osimertinib is standard-of-care therapy for previously untreated epidermal
growth factor receptor (EGFR) mutation–positive advanced non–small-cell lung cancer …
growth factor receptor (EGFR) mutation–positive advanced non–small-cell lung cancer …
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Whole chromosome and arm-level copy number alterations occur at high frequencies in
tumors, but their selective advantages, if any, are poorly understood. Here, utilizing …
tumors, but their selective advantages, if any, are poorly understood. Here, utilizing …
[HTML][HTML] Applications and analysis of targeted genomic sequencing in cancer studies
Abstract Next Generation Sequencing (NGS) has dramatically improved the flexibility and
outcomes of cancer research and clinical trials, providing highly sensitive and accurate high …
outcomes of cancer research and clinical trials, providing highly sensitive and accurate high …
The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding
of full molecular and immune landscape of ESCC remains limited, hindering the …
of full molecular and immune landscape of ESCC remains limited, hindering the …
Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric …
T Jogo, Y Nakamura, K Shitara, H Bando, H Yasui… - Clinical cancer …, 2021 - AACR
Purpose: FGFR2 amplification is associated with poor prognosis in advanced gastric cancer
and its subclonal heterogeneity has been revealed. Here, we examined whether circulating …
and its subclonal heterogeneity has been revealed. Here, we examined whether circulating …
Intratumor CMS heterogeneity impacts patient prognosis in localized colon cancer
Purpose: The consensus molecular subtypes (CMS) represent a significant advance in the
understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is …
understanding of intertumor heterogeneity in colon cancer. Intratumor heterogeneity (ITH) is …
Chromosome instability; implications in cancer development, progression, and clinical outcomes
R Vishwakarma, KJ McManus - Cancers, 2020 - mdpi.com
Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a
driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately …
driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately …
Tumour heterogeneity and evolutionary dynamics in colorectal cancer
DKH Chan, SJA Buczacki - Oncogenesis, 2021 - nature.com
Colorectal cancer (CRC) has a global burden of disease. Our current understanding of CRC
has progressed from initial discoveries which focused on the stepwise accumulation of key …
has progressed from initial discoveries which focused on the stepwise accumulation of key …