Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy

L Tang, GT Xu, JF Zhang - Neural regeneration research, 2023 - journals.lww.com
Diabetic retinopathy, characterized as a microangiopathy and neurodegenerative disease,
is the leading cause of visual impairment in diabetic patients. Many clinical features …

Recent insights into the etiopathogenesis of diabetic retinopathy and its management

A Biswas, AD Choudhury, S Agrawal… - Journal of Ocular …, 2024 - liebertpub.com
Purpose: Diabetic retinopathy (DR) is a microvascular retinal disease associated with
chronic diabetes mellitus, characterized by the damage of blood vessels in the eye. It is …

Delivering active molecules to the eye; the concept of electrospinning as potent tool for drug delivery systems

PI Siafaka, EÖ Bülbül, AN Miliotou, ID Karantas… - Journal of Drug Delivery …, 2023 - Elsevier
Ocular drug delivery is a challenging but fascinating topical route of administration. Although
the eye is easily accessible to common drug formulations such as drops, its complex …

The protective effects of neurotrophins and microRNA in diabetic retinopathy, nephropathy and heart failure via regulating endothelial function

S Shityakov, M Nagai, S Ergün, BM Braunger… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus is a common disease affecting more than 537 million adults worldwide.
The microvascular complications that occur during the course of the disease are widespread …

An improved object detection algorithm based on the Hessian matrix and conformable derivative

JE Lavín-Delgado, JE Solís-Pérez… - Circuits, Systems, and …, 2024 - Springer
In this paper, a newfangled technique for edge detection that combines the Khalil
conformable derivative and the Hessian matrix is developed and experimentally validated …

A mechanistic insight on phytoconstituents delivering hypoglycemic activity: a comprehensive overview

SS Raghav, B Kumar, NK Sethiya, A Kaul - Future Pharmacology, 2022 - mdpi.com
Diabetes is a long-term (chronic), challenging lifestyle (metabolic) disorder in which the
body cannot regulate the amount of sugar in the blood and majorly affecting endocrine …

Source-free active domain adaptation for diabetic retinopathy grading based on ultra-wide-field fundus images

J Ran, G Zhang, F Xia, X Zhang, J Xie… - Computers in Biology and …, 2024 - Elsevier
Abstract Domain adaptation (DA) is commonly employed in diabetic retinopathy (DR)
grading using unannotated fundus images, allowing knowledge transfer from labeled color …

Dual anti-angiogenic and anti-inflammatory action of tRNA-Cys-5-0007 in ocular vascular disease

Y Ma, Y Zhang, HY Zhang, Y Zhao, XM Li… - Journal of Translational …, 2024 - Springer
Background Intravitreal injections of angiogenesis inhibitors have proved efficacious in the
majority of patients with ocular angiogenesis. However, one-fourth of all treated patients fail …

Inefficacy of anti-VEGF therapy reflected in VEGF-mediated photoreceptor degeneration

X Xu, N Han, F Zhao, R Fan, Q Guo, X Han… - … Therapy-Nucleic Acids, 2024 - cell.com
Retinal neovascularization (RNV) is primarily driven by vascular endothelial growth factor
(VEGF). However, current anti-VEGF therapies are limited by short half-lives and repeated …

Effect of Chinese herbal compounds on ocular fundus signs and vision in conventional treated-persons with non-proliferative diabetic retinopathy: A systematic review …

X Li, J Zhang, R He, X Su, Z Li, X Xie - Frontiers in Endocrinology, 2022 - frontiersin.org
Background Changes in fundus signs and loss of visual acuity are an important basis for
screening and treating diabetic patients with retinopathy, and conventional Western …