LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy
machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5 …

The rapid and efficient phagocytic clearance of apoptotic cells, termed efferocytosis, is a
critical mechanism in the maintenance of tissue homeostasis. Removal of apoptotic cells …

Macroautophagy is a bulk degradation system in which double membrane-bound structures
called autophagosomes to deliver cytosolic materials to lysosomes. Autophagy promotes …

Glial engulfment of neuron-derived debris after trauma, during development, and in
neurodegenerative diseases supports nervous system functions. However, mechanisms …

Activation of PINK1 and Parkin in response to mitochondrial damage initiates a response
that includes phosphorylation of RAB7A at Ser72. Rubicon is a RAB7A binding negative …

Phosphatidylinositol-3-phosphate (PtdIns (3) P) is essential for cell survival, and its
intracellular synthesis is spatially and temporally regulated. It has major roles in two …

Autophagy is a catabolic process that targets its cargo for lysosomal degradation. In addition
to its function in maintaining tissue homeostasis, autophagy is recognized to play a context …

Autophagy is a lysosomal-dependent degradation process of eukaryotic cells responsible
for breaking down unnecessary and damaged intracellular components. Autophagic activity …

Autophagy is a highly regulated multi-step process that occurs at the basal level in almost all
cells. Although the deregulation of the autophagy process has been described in several …

Mutations in PLEKHM1 cause osteopetrosis in humans and rats. The germline and
osteoclast conditional deletions of Plekhm1 gene in mice lead to defective osteoclast bone …