This paper puts the case for the hippocampus as being central to the neuropathology and
pathophysiology of schizophrenia. The evidence comes from a range of approaches, both in …

To account for the complex genetics, the developmental biology, and the late
adolescent/early adulthood onset of schizophrenia, the “two-hit” hypothesis has gained …

Rates of serotonin synthesis were measured in the human brain using positron emission
tomography. The sensitivity of the method is indicated by the fact that measurements are …

The effects of the indolehallucinogen psilocybin, a mixed 5-HT 2 and 5-HT 1 agonist, on
regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET …

Background: The serotonin-1A (5HT1A) receptor system has been implicated in the
pathophysiology of major depression by postmortem studies of suicide victims and …

Abstract Rationale Serotonin (5-HT) neurotransmission is intimately linked to anxiety and
depression and a diverse body of evidence supports the involvement of the main inhibitory …

Background Pharmacological and postmortem investigations suggest that patients with
major depressive disorder have alterations in function or density of brain serotonin 1A (5-HT …

Certain animal models can greatly enhance our understanding of the neurobiology of
schizophrenia and can be used to predict the antipsychotic activity of compounds. Prepulse …

Objective Suicide is a major public health concern as each year 30000 people die by
suicide in the USA alone. In the teenage population, it is the second leading cause of death …

Serotonergic dysfunction is thought to contribute to the pathophysiology of schizophrenia but
the evidence has not been systematically synthesised before. We therefore systematically …