Cancer is a complex disease characterized by loss of cellular homeostasis through genetic
and epigenetic alterations. Emerging evidence highlights a role for histone variants and their …

Maintenance of an intact genome is essential for cellular and organismal homeostasis. The
centromere is a specialized chromosomal locus required for faithful genome inheritance at …

Chromosome instability is a critical event in cancer progression. Histone H3 variant CENP-A
plays a fundamental role in defining centromere identity, structure, and function but is …

Faithful chromosome segregation is essential for the maintenance of genomic integrity and
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …

Histone variants provide versatility in the basic unit of chromatin, helping to define dynamic
landscapes and cell fates. Maintaining genome integrity is paramount for the cell, and it is …

The centromeric histone H3 variant CENP-A is overexpressed in many cancers. The
mislocalization of CENP-A to noncentromeric regions contributes to chromosomal instability …

Chromosomal instability (CIN) is a hallmark of many cancers. Restricting the localization of
centromeric histone H3 variant CENP-A to centromeres prevents CIN. CENP-A …

In most species, the centromere is comprised of repetitive DNA sequences, which rapidly
evolve. Paradoxically, centromeres fulfill an essential function during mitosis, as they are the …

Chromatin integrity is key for cell homeostasis and for preventing pathological development.
Alterations in core chromatin components, histone proteins, recently came into the spotlight …

Tumour evolution is driven by both genetic and epigenetic changes. CENP-A, the
centromeric histone H3 variant, is an epigenetic mark that directly perturbs genetic stability …