Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying
genomic instability through radiotherapy and chemotherapy has been a powerful but …

PARP-1 (poly (ADP-ribose)-polymerase 1), mainly known for its protective role in DNA
repair, also regulates inflammatory processes. Notably, defects in DNA repair and chronic …

Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here
we demonstrate that the known synthetic lethal interaction between poly (ADP-ribose) …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a critical DNA repair enzyme in the base
excision repair pathway. Inhibitors of this enzyme comprise a new type of anticancer drug …

Gastric cancer (GC) is the fifth most frequently diagnosed cancer worldwide and the third
leading cause of cancer-related death with an oncological origin. Despite its decline in …

Defects in the DNA damage response (DDR) can lead to genome instability, producing
mutations or aberrations that promote the development and progression of cancer. But it …

Nanotechnology offers many possibilities to improve drug treatments, including with regard
to drug pharmacology. The current study reports a simple approach to improve cisplatin …

Gastric cancer (GC) has a poor prognosis due to its relentless proliferation and metastasis.
One of the reasons for this plight is the formidable angiogenesis ability of GC. Considering …

PARP‐1 holds major functions on chromatin, DNA damage repair and transcriptional
regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional …

Sterols are the important active ingredients of fungal secondary metabolites to induce death
of tumor cells. In our previous study, we found that ergosterol peroxide (5α, 8α …