2. INTRODUCTION The investigation of many fundamental processes in life sciences
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …

Abnormal shifts in the composition of gut microbiota contribute to the pathogenesis of
metabolic diseases, including obesity and type 2 diabetes (T2DM). The crosstalk between …

Haplotype-based methods offer a powerful approach to disease gene mapping, based on
the association between causal mutations and the ancestral haplotypes on which they …

Inherited genetic variation has a critical but as yet largely uncharacterized role in human
disease. Here we report a public database of common variation in the human genome: more …

Genetic factors strongly affect susceptibility to common diseases and also influence disease-
related quantitative traits. Identifying the relevant genes has been difficult, in part because …

We describe a map of 1.42 million single nucleotide polymorphisms (SNPs) distributed
throughout the human genome, providing an average density on available sequence of one …

Future advances in plant genomics will make it possible to scan a genome for
polymorphisms associated with qualitative and quantitative traits. Before this potential can …

The discovery of single nucleotide polymorphisms (SNPs) and insertions/deletions, which
are the basis of most differences between alleles, has been simplified by recent …

With the availability of a dense genome-wide map of single nucleotide polymorphisms
(SNPs), a central issue in human genetics is whether it is now possible to use linkage …

In this review, we describe recent empirical and theoretical work on the extent of linkage
disequilibrium (LD) in the human genome, comparing the predictions of simple population …