Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw.
They represent not only the primary tumor site, but also potential metastatic lesions, and …

Aortic disease has many forms including aortic aneurysm and dissection, aortic coarctation
or abnormalities in aortic function, such as loss of aortic distensibility. Genetic analysis in …

Background Millions of people suffer from Alzheimer's disease (AD) and Parkinson's
disease (PD) worldwide. Due to their complex pathology, no effective pharmacological …

The endothelium is the single-cell monolayer that lines the entire vasculature. The
endothelium has a barrier function to separate blood from organs and tissues but also has …

Background Transforming growth factor-β (TGF-β)-induced Epithelial-to-mesenchymal
transition (EMT) process is a fundamental target for preventing cervical cancer cells' …

Zingerone 1 (Zing) is one of the bioactive compounds of ginger rhizome (Zingiber officinale),
whose beneficial effects have been reported previously on reproductive organ …

Background Silibinin, the principal flavonoid derived from milk thistle seeds, has been
demonstrated to have strong inhibitory effects against human malignancies. The inhibitory …

Transforming growth factor (TGF)-β signalling pathways are intensively investigated
because of their diverse association with physiological and pathophysiological states. Smad …

Background: Piperine is a natural compound obtained from the Piper nigrum that exhibits
anti-proliferative and anti-cancer activity in cancer cell lines. We analyzed the cytotoxic effect …

Aging induces gradual accumulation of damages in cells and tissues, which leads to
physiological dysfunctions. Aging-associated muscle dysfunction is commonly seen in aged …