The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …

Biological sex differences refer to differences between males and females caused by the sex
chromosome complement (that is, XY or XX), reproductive tissues (that is, the presence of …

We report on the influence of~ 22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P< 1.28× 10− 11) independent association …

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some
heterologous infections, probably via induction of non-specific innate immune memory in …

Droplet single-cell RNA-sequencing (dscRNA-seq) has enabled rapid, massively parallel
profiling of transcriptomes. However, assessing differential expression across multiple …

Differences in susceptibility to immune-mediated diseases are determined by variability in
immune responses. In three studies within the Human Functional Genomics Project, we …

The quantification and characterization of circulating immune cells provide key indicators of
human health and disease. To identify the relative effects of environmental and genetic …

As part of the Human Functional Genomics Project, which aims to understand the factors that
determine the variability of immune responses, we investigated genetic variants affecting …

Background & Aims HDV infection causes severe chronic liver disease in individuals
infected with HBV. However, the factors associated with poor prognosis are largely …

Understanding the physiology and genetics of human hypoxia tolerance has important
medical implications, but this phenomenon has thus far only been investigated in high …