Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease

Y Tan, Y Zheng, D Xu, Z Sun, H Yang, Q Yin - Cell & bioscience, 2021 - Springer
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by the
deposition of extracellular aggregates of amyloid-β (Aβ), the formation of intraneuronal tau …

Molecular aspects of thyroid calcification

LB Ferreira, E Gimba, J Vinagre… - International Journal of …, 2020 - mdpi.com
In thyroid cancer, calcification is mainly present in classical papillary thyroid carcinoma
(PTC) and in medullary thyroid carcinoma (MTC), despite being described in benign lesions …

Cigarette smoke induces epithelial-to-mesenchymal transition, stemness, and metastasis in lung adenocarcinoma cells via upregulated RUNX-2/galectin-3 pathway

JR Sharma, H Agraval, UCS Yadav - Life Sciences, 2023 - Elsevier
Aims An elevated level of galectin-3, a carbohydrate-binding lectin implicated in
tumorigenesis, metastasis, and epithelial-mesenchymal transition (EMT), has been found in …

Integrated bioinformatics analysis reveals that the expression of cathepsin S is associated with lymph node metastasis and poor prognosis in papillary thyroid cancer

J Tan, X Qian, B Song, X An, T Cai… - Oncology …, 2018 - spandidos-publications.com
The prognosis of the majority of patients with papillary thyroid cancer (PTC) is excellent,
although there are patients who experience disease recurrence and progression. The aim of …

Immunomodulation exerted by galectins: a land of opportunity in rare cancers

L Díaz-Alvarez, GI López-Cortés… - Frontiers in …, 2023 - frontiersin.org
Rare cancers represent only 5% of newly diagnosed malignancies. However, in some
cases, they account for up to 50% of the deaths attributed to cancer in their corresponding …

LncRNA GNAS-AS1 knockdown inhibits keloid cells growth by mediating the miR-188-5p/RUNX2 axis

Y Liu, L Li, JY Wang, F Gao, X Lin, SS Lin… - Molecular and Cellular …, 2023 - Springer
Keloid is a common dermis tumor, occurring repeatedly, affecting the quality of patients' life.
Long non-coding RNAs (lncRNAs) have crucial regulatory capacities in skin scarring …

The effects of fumonisin B1 on intercellular communications and miRNA modulations: Non-genotoxic carcinogenesis mechanisms in human kidney cells

EF Karaman, M Abudayyak, ZR Guler, S Bektas… - Toxicology, 2024 - Elsevier
Abstract Fumonisin B1 (FB1), which is produced by Fusarium species, is one of the most
prevalent mycotoxins known to exert several toxic effects, particularly nephrotoxicity. While …

RUNX transcription factors: biological functions and implications in cancer

X Chen, L Wang, M Yang, W Zhao, J Tu, B Liu… - Clinical and …, 2024 - Springer
Runt-related transcription factors (RUNX) are a family of transcription factors that are
essential for normal and malignant hematopoietic processes. Their most widely recognized …

Transcription factor Runx2 changes the expression of some matricellular proteins in metastatic breast cancer cells

S Binay, E Kaptan - Molecular Biology Reports, 2022 - Springer
Background Runx2 is one of the runt-related genes that are overexpressed in human
cancers and contribute to metastasis. The cancer cell metastasis requires modifications of …

Gene expression profiles of neuroinflammatory responses in broad brain regions in rats repeatedly administered with N-methyl-N-nitrosourea for 28 days

X Zou, Y Watanabe, S Ozawa, Y Ebizuka… - The Journal of …, 2024 - jstage.jst.go.jp
Abstract N-methyl-N-nitrosourea (MNU) exposure impairs hippocampal neurogenesis in
rats. The present study investigated the gene expression profiles that were commonly up or …