Immunogenic cell stress and death

G Kroemer, C Galassi, L Zitvogel, L Galluzzi - Nature immunology, 2022 - nature.com
Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Targeting immunogenic cell death in cancer

A Ahmed, SWG Tait - Molecular oncology, 2020 - Wiley Online Library
Immunogenic cell death (ICD) is a type of cancer cell death triggered by certain
chemotherapeutic drugs, oncolytic viruses, physicochemical therapies, photodynamic …

Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future

S Sen, M Won, MS Levine, Y Noh… - Chemical Society …, 2022 - pubs.rsc.org
Cancer is the deadliest disease in the world behind heart disease. Sadly, this remains true
even as we suffer the ravages of the Covid-19 pandemic. Whilst current chemo-and …

Immunogenic cell death inducing metal complexes for cancer therapy

L Zhang, N Montesdeoca, J Karges… - Angewandte Chemie …, 2023 - Wiley Online Library
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that
metastases and tumor relapse are the leading causes of cancer‐associated deaths. While …

[HTML][HTML] Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

L Galluzzi, I Vitale, S Warren, S Adjemian… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune
response associated with immunological memory, provided they display sufficient …

Chemotherapy side-effects: not all DNA damage is equal

WMC van den Boogaard, DSJ Komninos, WP Vermeij - Cancers, 2022 - mdpi.com
Simple Summary The number of children and adults with cancer that are completely cured is
still increasing thanks to effective anti-cancer therapy, but they may be confronted with the …

Immunogenic cell death in cancer and infectious disease

L Galluzzi, A Buqué, O Kepp, L Zitvogel… - Nature Reviews …, 2017 - nature.com
Immunogenicity depends on two key factors: antigenicity and adjuvanticity. The presence of
exogenous or mutated antigens explains why infected cells and malignant cells can initiate …

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

C Donohoe, MO Senge, LG Arnaut… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Photodynamic therapy is a promising approach for cancer treatment that relies on the
administration of a photosensitizer followed by tumor illumination. The generated oxidative …

An ER‐targeting iridium (III) complex that induces immunogenic cell death in non‐small‐cell lung cancer

L Wang, R Guan, L Xie, X Liao, K Xiong… - Angewandte …, 2021 - Wiley Online Library
Immunogenic cell death (ICD) is a vital component of therapeutically induced anti‐tumor
immunity. An iridium (III) complex (Ir1), containing an N, N‐bis (2‐chloroethyl)‐azane …

[PDF][PDF] Immunological effects of conventional chemotherapy and targeted anticancer agents

L Galluzzi, A Buque, O Kepp, L Zitvogel, G Kroemer - Cancer cell, 2015 - cell.com
The tremendous clinical success of checkpoint blockers illustrates the potential of
reestablishing latent immunosurveillance for cancer therapy. Although largely neglected in …