The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

Reactive oxygen species (ROS) and their products are components of cell signaling
pathways and play important roles in cellular physiology and pathophysiology. Under …

Drug repositioning (also referred to as drug repurposing), the process of finding new uses of
existing drugs, has been gaining popularity in recent years. The availability of several …

Purpose Cervical cancer is the leading cause of cancer death among the 20 million women
with HIV worldwide. We sought to determine whether HIV infection affected survival in …

More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …

Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt pathway is a key cascade downstream
of several protein kinases, especially membrane-bound receptor tyrosine kinases, including …

The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …

The poors outcomes associated with pancreatic cancer clearly reflect the advanced stage of
disease at diagnosis for most patients. Through this lens, it is easy to lose sight of the fact …

The use of anti-HIV drugs as cancer treatments is not new. Azidothymidine was studied as
an antineoplastic in the 1990s, but despite promising in vitro data, clinical trials showed little …

HIV infected people are at higher risk of developing cancer, although it is globally
diminished in the era of highly active antiretroviral treatment (HAART). Recently …