While bone tissue is a hierarchically organized material, mathematical formulations of bone
remodeling are often defined on the level of a millimeter-sized representative volume …

Bone mechanobiology is the study of the physical, biological and mechanical processes that
continuously affect the multiscale multicellular system of the bone from the organ to the …

Patients at high risk of fracture due to metabolic diseases frequently undergo long-term
antiresorptive therapy. However, in some patients, treatment is unsuccessful in preventing …

Computational models are gaining importance not only for basic science, but also for the
analysis of clinical interventions and to support clinicians prior to intervention. Vertebroplasty …

Microstructures of cortical and cancellous bones are altered continually by load-adaptive
remodeling; in addition, their cellular mechanisms are similar despite the remarkably …

A bone loading estimation algorithm was previously developed that provides in vivo loading
conditions required for in vivo bone remodelling simulations. The algorithm derives a bone's …

Osteoporosis is a major medical burden and its impact is expected to increase in our aging
society. It is associated with low bone density and microstructural deterioration. Treatments …

When striving for reconstructing and predicting bone remodeling processes by means of
mathematical models, cell population models have become a popular option. From a …

Bone remodeling is a complex process involving cell–cell interactions, biochemical
signaling and mechanical stimuli. Early models of the biological aspects of remodeling were …

Because changes in the mechanical properties of bone are closely related to trabecular
bone remodeling, methods that consider the temporal morphological changes induced by …