Amino acid transporters revisited: New views in health and disease
P Kandasamy, G Gyimesi, Y Kanai… - Trends in biochemical …, 2018 - cell.com
Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
Role of glutamate excitotoxicity and glutamate transporter EAAT2 in epilepsy: Opportunities for novel therapeutics development
JL Green, WF Dos Santos, ACK Fontana - Biochemical pharmacology, 2021 - Elsevier
Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …
Mechanisms of glutamate transport
RJ Vandenberg, RM Ryan - Physiological reviews, 2013 - journals.physiology.org
l-Glutamate is the predominant excitatory neurotransmitter in the mammalian central
nervous system and plays important roles in a wide variety of brain functions, but it is also a …
nervous system and plays important roles in a wide variety of brain functions, but it is also a …
Retinal ischemia: mechanisms of damage and potential therapeutic strategies
Retinal ischemia is a common cause of visual impairment and blindness. At the cellular
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …
Reactive astrocytes as therapeutic targets for CNS disorders
ME Hamby, MV Sofroniew - Neurotherapeutics, 2010 - Elsevier
Reactive astrogliosis has long been recognized as a ubiquitous feature of CNS pathologies.
Although its roles in CNS pathology are only beginning to be defined, genetic tools are …
Although its roles in CNS pathology are only beginning to be defined, genetic tools are …
Molecular targets for antiepileptic drug development
BS Meldrum, MA Rogawski - Neurotherapeutics, 2007 - Elsevier
This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …
potential molecular targets, in conjunction with new information on the genetics of idiopathic …
The SLC1 high-affinity glutamate and neutral amino acid transporter family
Y Kanai, B Clémençon, A Simonin… - Molecular aspects of …, 2013 - Elsevier
Glutamate transporters play important roles in the termination of excitatory
neurotransmission and in providing cells throughout the body with glutamate for metabolic …
neurotransmission and in providing cells throughout the body with glutamate for metabolic …
Transporters for L‐glutamate: An update on their molecular pharmacology and pathological involvement
l‐Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five
types of high‐affinity Glu transporters (EAAT1–5) have been identified. The transporters …
types of high‐affinity Glu transporters (EAAT1–5) have been identified. The transporters …
Glutamate transporter EAAT2: regulation, function, and potential as a therapeutic target for neurological and psychiatric disease
K Takahashi, JB Foster, CLG Lin - Cellular and Molecular Life Sciences, 2015 - Springer
Glutamate is the predominant excitatory neurotransmitter in the central nervous system.
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of …
Current approaches to enhance glutamate transporter function and expression
ACK Fontana - Journal of neurochemistry, 2015 - Wiley Online Library
Abstract l‐glutamate is the predominant excitatory neurotransmitter in the CNS and has a
central role in a variety of brain functions. The termination of glutamate neurotransmission by …
central role in a variety of brain functions. The termination of glutamate neurotransmission by …