N-Triftosylhydrazones: A New Chapter for Diazo-Based Carbene Chemistry
Z Liu, P Sivaguru, G Zanoni, X Bi - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Over recent decades, N-sulfonylhydrazones have attracted significant attention
in academic and industrial contexts owing to their ease of preparation, versatile reactivity …
in academic and industrial contexts owing to their ease of preparation, versatile reactivity …
Organoboron Reagent‐Controlled Selective (Deutero) Hydrodefluorination
ZJ Shen, C Zhu, X Zhang, C Yang… - Angewandte …, 2023 - Wiley Online Library
Abstract (Deuterium‐labeled) CF2H‐and CFH2‐moieties are of high interest in drug
discovery. The high demand for the incorporation of these fluoroalkyl moieties into molecular …
discovery. The high demand for the incorporation of these fluoroalkyl moieties into molecular …
C–F bond functionalizations via fluorinated carbenes
Y Li, J Luo, Y Jiang - Organic Chemistry Frontiers, 2023 - pubs.rsc.org
Fluorinated carbenes take an important position in the synthesis of fluorine-containing
molecules in organic synthesis. When carbon centered carbenes are installed with fluorides …
molecules in organic synthesis. When carbon centered carbenes are installed with fluorides …
Construction of C–X (X = S, O, Se) Bonds via Lewis Acid-Promoted Functionalization of Trifluoromethylarenes
J Xu, JW Liu, R Wang, J Yang, KK Zhao, HJ Xu - ACS Catalysis, 2023 - ACS Publications
The conversion of easily available trifluoromethylarenes through C–F bond activation
provides an attractive pathway for rapid access to difluorobenzylic substructures in …
provides an attractive pathway for rapid access to difluorobenzylic substructures in …
Late‐Stage Modification of Drugs via Alkene Formal Insertion into Benzylic C− F Bond
J Wang, Y Wang, Y Liang, L Zhou, L Liu… - Angewandte …, 2023 - Wiley Online Library
C− F insertion of carbon‐atom units is underdeveloped although it poses significant
potential applications in both drug discovery and development. Herein, we report a …
potential applications in both drug discovery and development. Herein, we report a …
Selective defluoroalkylation and hydrodefluorination of trifluoromethyl groups photocatalyzed by dihydroacridine derivatives
SY Li, XY Yang, PH Shen, L Xu, J Xu… - The Journal of …, 2023 - ACS Publications
The selective functionalization of trifluoromethyl groups through C–F cleavage poses a
significant challenge due to the high bond energy of the C (sp3)–F bonds. Herein, we …
significant challenge due to the high bond energy of the C (sp3)–F bonds. Herein, we …
Photocatalytic redox-neutral selective single C (sp 3)–F bond activation of perfluoroalkyl iminosulfides with alkenes and water
T Wang, YY Zong, T Huang, XL Jin, LZ Wu, Q Liu - Chemical Science, 2023 - pubs.rsc.org
Visible-light-promoted site-selective and direct C–F bond functionalization of polyfluorinated
iminosulfides was accomplished with alkenes and water under redox-neutral conditions …
iminosulfides was accomplished with alkenes and water under redox-neutral conditions …
Photoredox Catalyzed Single C−F Bond Activation of Trifluoromethyl Ketones: A Solvent Controlled Divergent Access of gem‐Difluoromethylene Containing Scaffolds
Selective defluorinative functionalization of trifluoromethyl ketones is a long‐standing
challenge owing to the exhaustive mode of the process. To meet the demands for the …
challenge owing to the exhaustive mode of the process. To meet the demands for the …
Copper-catalyzed crosscoupling of vinyl nitrenes and CF 3-carbenes to synthesize CF 3-2-azadienes
Y Jiao, T Wu, X Zhang, Y Jiang - Organic Chemistry Frontiers, 2024 - pubs.rsc.org
A unique and efficient copper catalytic system has been established to synthesize
fluorinated 2-azadienes from isoxazoles and CF3-N-tosylhydrazones via crosscoupling …
fluorinated 2-azadienes from isoxazoles and CF3-N-tosylhydrazones via crosscoupling …
Stereoselective hydrodefluorination of CF 3-substituted alkenes and gem-difluoroalkenes by H−
D Bai, X Li, F Wu, J Chang - Organic Chemistry Frontiers, 2024 - pubs.rsc.org
The hydride anion addition catalysed by Zn2+ enables the stereoselective and
regioselective hydrodefluorination of fluoroolefins and polyfluoroarenes. This method allows …
regioselective hydrodefluorination of fluoroolefins and polyfluoroarenes. This method allows …