Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …

The neuroendocrine system governs essential survival and homeostatic functions. For
example, growth is needed for development, thermoregulation maintains optimal core …

Obesity and type 2 diabetes mellitus (T2DM) often occur together and affect a growing
number of individuals in both the developed and developing worlds. Both are associated …

The central nervous system and adipose tissue interact through complex communication.
This bidirectional signaling regulates metabolic functions. The hypothalamus, a key …

Unique subpopulations of specialized metabolic sensing neurons reside in a distributed
network throughout the brain and respond to alterations in ambient levels of various …

Metabolic sensing neurons in the ventromedial hypothalamus (VMH) alter their activity when
ambient levels of metabolic substrates, such as glucose and fatty acids (FA), change. To …

We assessed the mechanisms by which specialized hypothalamic ventromedial nucleus
(VMN) neurons utilize both glucose and long-chain fatty acids as signaling molecules to …

Obesity and Type 2 diabetes are major worldwide public health issues today. A relationship
between total fat intake and obesity has been found. In addition, the mechanisms of long …

Fatty acid (FA)-sensitive neurons are present in the brain, especially the hypothalamus, and
play a key role in the neural control of energy and glucose homeostasis including feeding …

Hypothalamic “metabolic-sensing” neurons sense glucose and fatty acids (FAs) and play an
integral role in the regulation of glucose, energy homeostasis, and the development of …