Stress granules (SGs) are phase-separated, membraneless, cytoplasmic ribonucleoprotein
(RNP) assemblies whose primary function is to promote cell survival by condensing …

Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive …

Genetic analyses of patients with amyotrophic lateral sclerosis (ALS) have revealed a strong
association between mutations in genes encoding many RNA-binding proteins (RBPs) …

Formation of cytoplasmic RNA-protein structures called stress granules (SGs) is a highly
conserved cellular response to stress. Abnormal metabolism of SGs may contribute to the …

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate
the progression of many CNS pathologies both acute and chronic. The role of adaptor …

Liquid-liquid phase separation (LLPS) is a rapidly growing research focus due to numerous
demonstrations that many cellular proteins phase-separate to form biomolecular …

Neurodegenerative diseases (NDs) constitute a group of disorders characterized by the
progressive deterioration of nervous system functionality. Currently, the precise etiological …

In amyotrophic lateral sclerosis (ALS) patients, loss of cellular homeostasis within cortical
and spinal cord motor neurons triggers the activation of the integrated stress response (ISR) …

Abstract TAR DNA binding protein 43 (TDP-43) pathology is a key feature of over 95% of
amyotrophic lateral sclerosis (ALS) and nearly half of frontotemporal dementia (FTD) cases …