The suite of currently used drugs can be divided into two categories–traditional 'small
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …

In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various
neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of …

Throughout evolution, numerous proteins have been convergently recruited into the venoms
of various animals, including centipedes, cephalopods, cone snails, fish, insects (several …

In the face of rising population, food insecurity is emerging as a global challenge. Nutritious
sources of food are frantically being searched for and so far underutilized food candidates …

Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …

Antibodies have proved to be a valuable mode of therapy for numerous diseases, mainly
owing to their high target binding affinity and specificity. Unfortunately, antibodies are also …

Cone snails are carnivorous marine gastropods that have evolved potent venoms to capture
their prey. These venoms comprise a rich and diverse cocktail of peptide toxins, or …

Insect-derived ingredients, including whole larvae, protein-rich meal, and oil, have been
extensively studied in recent years and shown to be a sustainable source of quality nutrition …

Spider venom, a factor that has played a decisive role in the evolution of one of the most
successful groups of living organisms, is reviewed. Unique molecular diversity of venom …