Double-strand DNA breaks (DSBs) are the most lethal type of DNA damage, making DSB
repair critical for cell survival. However, some DSB repair pathways are mutagenic and …

Break-induced replication (BIR) is a pathway specialized in repair of double-strand DNA
breaks with only one end capable of invading homologous template that can arise following …

Break-induced replication (BIR) repairs one-ended double-strand breaks in DNA similar to
those formed by replication collapse or telomere erosion, and it has been implicated in the …

Non-allelic recombination between homologous repetitive elements contributes to evolution
and human genetic disorders. Here, we combine short-and long-DNA read sequencing of …

DNA double-strand breaks (DSBs) are among the most serious forms of DNA damage. In
humans, DSBs are repaired mainly by non-homologous end joining (NHEJ) and …

This review of the scientific and technological developments on New Genomic Techniques
(NGTs) is aimed to provide the technical status of NGTs with respect to their diverse …

Human chromosomes are arranged in a linear and conserved sequence order that
undergoes further spatial folding within the three-dimensional space of the nucleus …

Background Spontaneous double‐stranded DNA breaks (DSBs) frequently occur within the
genome of all living organisms and must be well repaired for survival. Recently, more …

Repeat-mediated deletions (RMDs) often involve repetitive elements (eg, short interspersed
elements) with sequence divergence that is separated by several kilobase pairs (kbps). We …

While gene drive strategies have been proposed to aid in the control of mosquito-borne
diseases, additional genome engineering technologies may be required to establish a …