Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

EBV was the first human virus to be directly implicated in carcinogenesis. It infects> 90% of
the world's population. Although most humans coexist with the virus without serious …

Familial cylindromatosis is an autosomal dominant predisposition to tumours of skin
appendages called cylindromas. Familial cylindromatosis is caused by mutations in a gene …

▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β,
and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF …

Tumor necrosis factor receptor-associated factors (TRAFS) were initially discovered as
adaptor proteins that couple the tumor necrosis factor receptor family to signaling pathways …

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular
proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic …

▪ Abstract Successful viral replication requires not only the efficient production and spread of
progeny, but also evasion of host defense mechanisms that limit replication by killing …

Members of the TNF receptor superfamily play pivotal roles in numerous biological events in
metazoan organisms. Ligand-mediated trimerization by corresponding homo-or …

The Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) is essential for the
immortalization of human B cells and is linked etiologically to several human tumors. LMP1 …

The signaling pathways that regulate cell survival are beginning to be defined. Receptors
such as Fas and tumor necrosis factor receptor type I (TNFRI) have been shown to be …