Targeting membrane-bound bacterial cell wall precursors: a tried and true antibiotic strategy in nature and the clinic
Since Fleming's discovery of penicillin nearly a century ago, a bounty of natural product
antibiotics have been discovered, many of which continue to be of clinical importance today …
antibiotics have been discovered, many of which continue to be of clinical importance today …
Undecaprenyl phosphate translocases confer conditional microbial fitness
The microbial cell wall is essential for maintenance of cell shape and resistance to external
stressors. The primary structural component of the cell wall is peptidoglycan, a glycopolymer …
stressors. The primary structural component of the cell wall is peptidoglycan, a glycopolymer …
Lipid-Centric Approaches in Combating Infectious Diseases: Antibacterials, Antifungals and Antivirals with Lipid-Associated Mechanisms of Action
OS Ostroumova, SS Efimova - Antibiotics, 2023 - mdpi.com
One of the global challenges of the 21st century is the increase in mortality from infectious
diseases against the backdrop of the spread of antibiotic-resistant pathogenic …
diseases against the backdrop of the spread of antibiotic-resistant pathogenic …
The utility of Streptococcus mutans undecaprenol kinase for the chemoenzymatic synthesis of diverse non-natural isoprenoids
Isoprene chemoenzymatic cascades (ICCs) overcome the complexity of natural pathways by
leveraging a streamlined two-enzyme cascade, facilitating efficient synthesis of C5-isoprene …
leveraging a streamlined two-enzyme cascade, facilitating efficient synthesis of C5-isoprene …
Bacitracin enhances ceftriaxone susceptibility of the high-level ceftriaxone-resistant gonococcal FC428 clone
Y Gu, S Song, Q Zhu, R Jiao, X Lin, F Yang… - Microbiology …, 2023 - Am Soc Microbiol
Neisseria gonorrhoeae is a multidrug-resistant bacterial pathogen for which ceftriaxone
mono-antimicrobial therapy and ceftriaxone plus azithromycin dual-antimicrobial therapy are …
mono-antimicrobial therapy and ceftriaxone plus azithromycin dual-antimicrobial therapy are …
Synthesis and structure–activity relationship of novel thiazole aminoguanidines against MRSA and Escherichia coli
P Yang, HZ Liu, YS Wang, H Qi, LL Wang… - RSC Medicinal …, 2024 - pubs.rsc.org
Novel lead thiazole aminoguanidines exhibited strong activity against Gram-positive
bacteria. The potential targets of these substances are undecaprenyl diphosphate synthase …
bacteria. The potential targets of these substances are undecaprenyl diphosphate synthase …
Optimizations of lipid II synthesis: an essential glycolipid precursor in bacterial cell wall synthesis and a validated antibiotic target
M Karak, CR Cloonan, BR Baker… - Beilstein Journal of …, 2024 - beilstein-journals.org
Lipid II is an essential glycolipid found in bacteria. Accessing this valuable cell wall
precursor is important both for studying cell wall synthesis and for studying/identifying novel …
precursor is important both for studying cell wall synthesis and for studying/identifying novel …
[PDF][PDF] Elucidating the permeation mechanisms of the TRPV and TRPM ion channels using in silico electrophysiology
CM Ives - 2023 - discovery.dundee.ac.uk
I declare that this thesis is based on results obtained from research which I have personally
carried out in the School of Life Sciences at the University of Dundee. I declare that the …
carried out in the School of Life Sciences at the University of Dundee. I declare that the …
Unveiling an Innovative Iteration of the Isoprenol Pathways for Non-Natural Isoprenoid Synthesis
V Kumar, BP Johnson, PS Mandal, DR Sheffield… - Available at SSRN … - papers.ssrn.com
Isoprenol pathways diverge from the complexity of natural routes by leveraging a
streamlined two-enzyme cascade, facilitating efficient synthesis of C5-isoprene diphosphate …
streamlined two-enzyme cascade, facilitating efficient synthesis of C5-isoprene diphosphate …