Polycomb group complexes, which are known to regulate homeotic genes, have now been
found to control hundreds of other genes in mammals and insects. First believed to …

The Wnt signaling pathway controls cell proliferation and body patterning throughout
development. A surprising number of cytoplasmic Wnt regulators (eg, β-catenin, Bcl-9/Lgs …

Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their
quantitative determination may be informative about pathogenic conditions. We searched for …

Polycomb group protein Ezh2, one of the key regulators of development in organisms from
flies to mice, exerts its epigenetic function through regulation of histone methylation. Here …

The human immunodeficiency virus (HIV) Tat protein is acetylated by the transcriptional
coactivator p300, a necessary step in Tat-mediated transactivation. We report here that Tat is …

Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial
developmental and physiological processes in the cell. More recently, they have been found …

The epigenetic maintenance of gene expression patterns is essential for developing and
maintaining the diverse types of cell that cooperate to form the larger organism. Recent data …

HIV-1-infected lymphocytes improperly respond to T cell antigen receptor (TCR) stimulation.
To document this phenomenon, we studied the capacity of HIV-1-infected lymphocytes to …

The HIV Nef protein mediates endocytosis of surface receptors that correlates with disease
progression, but the link between this Nef function and HIV pathogenesis is not clear. Here …

Polycomb transcriptional silencing machinery is implicated in the maintenance of precursor
fates, but how this repression is reversed to allow cell differentiation is unknown. Here we …