The hypothalamus (“hypo” meaning below, and “thalamus” meaning bed) consists of
regulatory circuits that support basic life functions that ensure survival. Sitting at the interface …

This review analyzes the published evidence regarding maternal factors that influence the
developmental programming of long-term adiposity in humans and animals via the central …

The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

The hypothalamus plays a crucial role in the progression of obesity and diabetes; however,
its structural complexity and cellular heterogeneity impede targeted treatments. Here, we …

Human neural organoids offer an exciting opportunity for studying inaccessible human-
specific brain development; however, it remains unclear how precisely organoids …

Over the last decades, thyroid hormones (THs) signaling has been established as a key
signaling cue for the proper maintenance of brain functions in adult mammals, including …

The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its
fundamental role, the cells and signalling pathways that specify this unique region of the …

The hypothalamic-pituitary-ovarian (HPO) axis represents a central neuroendocrine network
essential for reproductive function. Despite its critical role, the intrinsic heterogeneity within …

The hypothalamus is a region of the brain that plays an important role in regulating body
functions and behaviors. There is a growing interest in human pluripotent stem cells …

The brain is the central hub of the entire nervous system. Its development is a lifelong
process guided by a genetic blueprint. Understanding how genes influence brain …