[HTML][HTML] Limitations and challenges in protein stability prediction upon genome variations: towards future applications in precision medicine
Protein stability predictions are becoming essential in medicine to develop novel
immunotherapeutic agents and for drug discovery. Despite the large number of …
immunotherapeutic agents and for drug discovery. Despite the large number of …
Systematic evaluation of computational tools to predict the effects of mutations on protein stability in the absence of experimental structures
Abstract Changes in protein sequence can have dramatic effects on how proteins fold, their
stability and dynamics. Over the last 20 years, pioneering methods have been developed to …
stability and dynamics. Over the last 20 years, pioneering methods have been developed to …
Computational insight into in silico analysis and molecular dynamics simulation of the dimer interface residues of ALS-linked hSOD1 forms in apo/holo states: a …
HD Zaji, B Seyedalipour, HM Hanun, P Baziyar… - 3 Biotech, 2023 - Springer
The aggregation of misfolded SOD1 proteins in neurodegenerative illnesses is a key
pathological hallmark in amyotrophic lateral sclerosis (ALS). SOD1 is stabilized and …
pathological hallmark in amyotrophic lateral sclerosis (ALS). SOD1 is stabilized and …
Biochemical and biophysical properties of the novel ALS-linked hSOD1 mutants: an experimental study accompanied by in silico analysis
N Namadyan, B Seyedalipour, S Hosseinkhani… - Journal of the Iranian …, 2023 - Springer
Familial amyotrophic lateral sclerosis (fALS) is a neurodegenerative disorder; approximately
20% are caused by dominant mutations in the gene encoding Cu/Zn human superoxide …
20% are caused by dominant mutations in the gene encoding Cu/Zn human superoxide …
Effects of the COVID-19 pandemic: new approaches for accelerated delivery of gene to first-in-human CMC data for recombinant proteins
H Broly, J Souquet, A Beck - MAbs, 2023 - Taylor & Francis
The COVID-19 pandemic highlighted the urgent need for life-saving treatments, including
vaccines, drugs, and therapeutic antibodies, delivered at unprecedented speed. During this …
vaccines, drugs, and therapeutic antibodies, delivered at unprecedented speed. During this …
Role of gamma radiation as an agent modulator of Mucor subtilissimus UCP1262 Fibrinolytic Enzyme (MsFE)
KBB Cardoso, TP Nascimento, PC Correia… - Process …, 2024 - Elsevier
Thrombosis is a dangerous condition that can result in major damage. Fibrinolytic enzymes
are significant therapeutic agents for thrombosis. This study focused on MsFE, a fibrinolytic …
are significant therapeutic agents for thrombosis. This study focused on MsFE, a fibrinolytic …
Prediction of mutation-induced protein stability changes based on the geometric representations learned by a self-supervised method
SS Li, ZM Liu, J Li, YB Ma, ZY Dong, JW Hou… - BMC …, 2024 - Springer
Background Thermostability is a fundamental property of proteins to maintain their biological
functions. Predicting protein stability changes upon mutation is important for our …
functions. Predicting protein stability changes upon mutation is important for our …
TAK1 may promote the development of diabetic nephropathy by reducing the stability of SnoN protein
Y Wang, Y Mao, X Zhang, H Liu, W Peng, L Liang… - Life sciences, 2019 - Elsevier
Aims This study aimed to investigate the role of transforming growth factor-β-activated
protein kinase 1 (TAK1) in the development of diabetic nephropathy (DN) by regulating the …
protein kinase 1 (TAK1) in the development of diabetic nephropathy (DN) by regulating the …
[图书][B] Towards rational design of aggregation-resistant protein variants
G Meric - 2021 - search.proquest.com
Proteins have been used for therapeutic purposes since the late 19 th century, and as of
2017, hundreds of therapeutic peptides and proteins had been approved by US-FDA for …
2017, hundreds of therapeutic peptides and proteins had been approved by US-FDA for …
Degradation of Wheat Germ Agglutinin and Amylase-Trypsin Inhibitors During Sourdough Fermentation
LE Rojas Tovar - 2020 - era.library.ualberta.ca
Abstract Non Celiac Wheat Sensitivity (NCWS), an intolerance to the ingestion of wheat
products, has increased considerably during the past few years. In sensitive individuals …
products, has increased considerably during the past few years. In sensitive individuals …