Sirolimus and mTOR inhibitors: a review of side effects and specific management in solid organ transplantation

LS Nguyen, M Vautier, Y Allenbach, N Zahr… - Drug safety, 2019 - Springer
Inhibitors of mechanistic target of rapamycin (mTOR inhibitors) are used as antiproliferative
immunosuppressive drugs and have many clinical applications in various drug …

Cellular signalling and photobiomodulation in chronic wound repair

TS Leyane, SW Jere, NN Houreld - International Journal of Molecular …, 2021 - mdpi.com
Photobiomodulation (PBM) imparts therapeutically significant benefits in the healing of
chronic wounds. Chronic wounds develop when the stages of wound healing fail to progress …

Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro

A Shabbir, A Cox, L Rodriguez-Menocal… - Stem cells and …, 2015 - liebertpub.com
Although chronic wounds are common and continue to be a major cause of morbidity and
mortality, treatments for these conditions are lacking and often ineffective. A large body of …

[HTML][HTML] Strategies for the management of adverse events associated with mTOR inhibitors

B Kaplan, Y Qazi, JR Wellen - Transplantation reviews, 2014 - Elsevier
Mammalian target of rapamycin (mTOR) inhibitors are used as potent immunosuppressive
agents in solid-organ transplant recipients (everolimus and sirolimus) and as antineoplastic …

Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing

SW Jere, NN Houreld, H Abrahamse - Cytokine & Growth Factor Reviews, 2019 - Elsevier
Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with
increased or reduced mTOR and GSK3β activity influences the wound repair process …

[HTML][HTML] ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious …

M Reinwald, JT Silva, NJ Mueller, J Fortún… - Clinical Microbiology …, 2018 - Elsevier
Background The present review is part of the European Society of Clinical Microbiology and
Infectious Diseases (ESCMID) Study Group for Infections in Compromised Hosts (ESGICH) …

Nanomaterials for wound healing: scope and advancement

I Kalashnikova, S Das, S Seal - Nanomedicine, 2015 - Taylor & Francis
Innovative methods for treating impaired and hard-to-heal wounds are needed. Novel
strategies are needed for faster healing by reducing infection, moisturizing the wound …

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis

R Iglesias-Bartolome, V Patel, A Cotrim… - Cell stem cell, 2012 - cell.com
The integrity of the epidermis and mucosal epithelia is highly dependent on resident self-
renewing stem cells, which makes them vulnerable to physical and chemical insults …

The PI3K-Akt-mTOR and associated signaling pathways as molecular drivers of immune-mediated inflammatory skin diseases: update on therapeutic strategy using …

T Roy, ST Boateng, MB Uddin, S Banang-Mbeumi… - Cells, 2023 - mdpi.com
The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin
(mTOR) signaling pathway has been implicated in various immune-mediated inflammatory …

A biocompatible sodium alginate/povidone iodine film enhances wound healing

M Summa, D Russo, I Penna, N Margaroli… - European Journal of …, 2018 - Elsevier
In the last few years, there has been an increasing tendency to use natural polymers for the
fabrication of dressings for wound and burn management. Among them, alginate, a …