Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly
exposed to microbes and their products. However, the role of microbes in itch generation is …

Atopic dermatitis is increasing worldwide in correlation with air pollution. Various organic
components of pollutants activate the transcription factor AhR (aryl hydrocarbon receptor) …

Atopic dermatitis (AD) is a chronic itch and inflammatory disorder of the skin that affects one
in ten people. Patients suffering from severe AD eventually progress to develop asthma and …

Itch is described as an irritating sensation that triggers a desire to scratch. However, this
definition hardly seems fitting for the millions of people who suffer from intractable itch …

Relentless, repetitive itching and scratching is a debilitating feature of many chronic
inflammatory skin disorders such as atopic dermatitis. While well known clinically, this itch …

Itch is a defining symptom of atopic dermatitis. Crosstalk between keratinocytes, the immune
system and non‐histaminergic sensory nerves is responsible for the pathophysiology of …

Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for
minutes to hours. However, the neural basis for this effect is unclear, and the underlying …

The spinal cord integrates and relays somatosensory input, leading to complex motor
responses. Research over the past couple of decades has identified transcription factor …