Phosphoinositides: tiny lipids with giant impact on cell regulation

T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

A short history of blebbing

GT Charras - Journal of microscopy, 2008 - Wiley Online Library
Blebs are protrusions of the cell membrane. They are the result of actomyosin contractions of
the cortex, which cause either transient detachment of the cell membrane from the actin …

Central roles of small GTPases in the development of cell polarity in yeast and beyond

HO Park, E Bi - Microbiology and molecular biology reviews, 2007 - Am Soc Microbiol
The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

Mechanisms of cell polarization

WJ Rappel, L Edelstein-Keshet - Current opinion in systems biology, 2017 - Elsevier
Cell polarization is a key step in the migration, development, and organization of eukaryotic
cells, both at the single cell and multicellular level. Research on the mechanisms that give …

The origins of phagocytosis and eukaryogenesis

N Yutin, MY Wolf, YI Wolf, EV Koonin - Biology direct, 2009 - Springer
Background Phagocytosis, that is, engulfment of large particles by eukaryotic cells, is found
in diverse organisms and is often thought to be central to the very origin of the eukaryotic …

[HTML][HTML] Luminescent dual sensors reveal extracellular pH-gradients and hypoxia on chronic wounds that disrupt epidermal repair

S Schreml, RJ Meier, M Kirschbaum, SC Kong… - Theranostics, 2014 - ncbi.nlm.nih.gov
Wound repair is a quiescent mechanism to restore barriers in multicellular organisms upon
injury. In chronic wounds, however, this program prematurely stalls. It is known that patterns …

A two-step search and run response to gradients shapes leukocyte navigation in vivo

A Georgantzoglou, H Poplimont, HA Walker… - Journal of Cell …, 2022 - rupress.org
Migrating cells must interpret chemical gradients to guide themselves within tissues. A long-
held principle is that gradients guide cells via reorientation of leading-edge protrusions …

The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair

ST Christensen, SF Pedersen, P Satir, IR Veland… - Current topics in …, 2008 - Elsevier
Cell cycle control and migration are critical processes during development and maintenance
of tissue functions. Recently, primary cilia were shown to take part in coordination of the …

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells

M Ernkvist, NL Persson, S Audebert… - Blood, The Journal …, 2009 - ashpublications.org
Abstract Controlled regulation of Rho GTPase activity is an essential component mediating
growth factor–stimulated migration. We have previously shown that angiomotin (Amot), a …

Angiomotin regulates endothelial cell migration during embryonic angiogenesis

K Aase, M Ernkvist, L Ebarasi, L Jakobsson… - Genes & …, 2007 - genesdev.cshlp.org
The development of the embryonic vascular system into a highly ordered network requires
precise control over the migration and branching of endothelial cells (ECs). We have …