Current state of melanoma diagnosis and treatment

LE Davis, SC Shalin, AJ Tackett - Cancer biology & therapy, 2019 - Taylor & Francis
Melanoma is the deadliest form of skin cancer. In the early stages, melanoma can be treated
successfully with surgery alone and survival rates are high, but after metastasis survival …

Quantitative mass spectrometry-based proteomics: an overview

S Rozanova, K Barkovits, M Nikolov, C Schmidt… - Quantitative methods in …, 2021 - Springer
In recent decades, mass spectrometry has moved more than ever before into the front line of
protein-centered research. After being established at the qualitative level, the more …

[HTML][HTML] Large-scale multi-omic analysis of COVID-19 severity

KA Overmyer, E Shishkova, IJ Miller, J Balnis… - Cell systems, 2021 - cell.com
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …

[HTML][HTML] SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry

J Kee, S Thudium, DM Renner, K Glastad, K Palozola… - Nature, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …

Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …

ECB Johnson, EB Dammer, DM Duong, L Ping… - Nature medicine, 2020 - nature.com
Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

Prioritized mass spectrometry increases the depth, sensitivity and data completeness of single-cell proteomics

RG Huffman, A Leduc, C Wichmann, M Di Gioia… - Nature …, 2023 - nature.com
Major aims of single-cell proteomics include increasing the consistency, sensitivity and
depth of protein quantification, especially for proteins and modifications of biological interest …

An introduction to mass spectrometry-based proteomics

SR Shuken - Journal of Proteome Research, 2023 - ACS Publications
Mass spectrometry is unmatched in its versatility for studying practically any aspect of the
proteome. Because the foundations of mass spectrometry-based proteomics are complex …

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

S Rafiq, OO Yeku, HJ Jackson, TJ Purdon… - Nature …, 2018 - nature.com
The efficacy of chimeric antigen receptor (CAR) T cell therapy against poorly responding
tumors can be enhanced by administering the cells in combination with immune checkpoint …

Data‐independent acquisition mass spectrometry‐based proteomics and software tools: a glimpse in 2020

F Zhang, W Ge, G Ruan, X Cai, T Guo - Proteomics, 2020 - Wiley Online Library
This review provides a brief overview of the development of data‐independent acquisition
(DIA) mass spectrometry‐based proteomics and selected DIA data analysis tools. Various …

Applications of proteomics in ovarian cancer: dawn of a new era

A Ghose, SVN Gullapalli, N Chohan, A Bolina… - Proteomes, 2022 - mdpi.com
The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …