Exactly half a century has passed since the launch of the first documented research project
(1965 Dendral) on computer‐assisted organic synthesis. Many more programs were created …

Currently, the number of new cancer cases and deaths worldwide is increasing year on
year. In addition to the requirement for cancer prevention, the top priority is still to seek the …

Training algorithms to computationally plan multistep organic syntheses has been a
challenge for more than 50 years,,,,,–. However, the field has progressed greatly since the …

By the end of the twentieth century, the interest in natural compounds as probable sources of
drugs has declined and was replaced by other strategies such as molecular target-based …

Presented herein is a condition-controlled selective synthesis of pyrazolonyl
spirodihydroquinolines or pyrazolonyl spiroindolines through formal [5+ 1] or [4+ 1] …

Covering: 2000 up to 2020 Few classes of natural products have inspired as many chemists
and biologists as have the iboga alkaloids. This family of monoterpenoid indole alkaloids …

A catalyst-free gem-difluorination/spirocyclization reaction has been successfully developed
for the synthesis of gem-difluorinated C2-spiroindoline derivatives from indole-2 …

The new melokhanines A–J (1–10) and 22 known (11–32) alkaloids were isolated from the
twigs and leaves of Melodinus khasianus. The new compounds and their absolute …

Indole alkaloids, which are abundant in nature, are a significant source of pharmacologically
active compounds. Indole alkaloids have the potential to exert anticancer activity via various …

Studies in Natural Products Chemistry, Volume 79 covers the synthesis, testing and
recording of the medicinal properties of natural products, providing cutting-edge accounts of …