Innovation in layer-by-layer assembly
Methods for depositing thin films are important in generating functional materials for diverse
applications in a wide variety of fields. Over the last half-century, the layer-by-layer assembly …
applications in a wide variety of fields. Over the last half-century, the layer-by-layer assembly …
Microfluidic organ-on-a-chip models of human liver tissue
The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …
Multivascular networks and functional intravascular topologies within biocompatible hydrogels
Solid organs transport fluids through distinct vascular networks that are biophysically and
biochemically entangled, creating complex three-dimensional (3D) transport regimes that …
biochemically entangled, creating complex three-dimensional (3D) transport regimes that …
Hepatitis E virus: advances and challenges
At least 20 million hepatitis E virus (HEV) infections occur annually, with> 3 million
symptomatic cases and∼ 60,000 fatalities. Hepatitis E is generally self-limiting, with a case …
symptomatic cases and∼ 60,000 fatalities. Hepatitis E is generally self-limiting, with a case …
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix
BE Uygun, A Soto-Gutierrez, H Yagi, ML Izamis… - Nature medicine, 2010 - nature.com
Orthotopic liver transplantation is the only available treatment for severe liver failure, but it is
currently limited by organ shortage. One technical challenge that has thus far limited the …
currently limited by organ shortage. One technical challenge that has thus far limited the …
Skin tissue generation by laser cell printing
L Koch, A Deiwick, S Schlie, S Michael… - Biotechnology and …, 2012 - Wiley Online Library
For the aim of ex vivo engineering of functional tissue substitutes, Laser‐assisted BioPrinting
(LaBP) is under investigation for the arrangement of living cells in predefined patterns. So far …
(LaBP) is under investigation for the arrangement of living cells in predefined patterns. So far …
In vitro models for liver toxicity testing
VY Soldatow, EL LeCluyse, LG Griffith… - Toxicology …, 2013 - academic.oup.com
Over the years, various liver-derived in vitro model systems have been developed to enable
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …
In vitro and in vivo models of non-alcoholic fatty liver disease: a critical appraisal
PA Soret, J Magusto, C Housset… - Journal of clinical medicine, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …
A vascularized model of the human liver mimics regenerative responses
Liver regeneration is a well-orchestrated process that is typically studied in animal models.
Although previous animal studies have offered many insights into liver regeneration, human …
Although previous animal studies have offered many insights into liver regeneration, human …