Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty

C Badowski, B He, LX Garmire - NPJ precision oncology, 2022 - nature.com
Cancer ranks as one of the deadliest diseases worldwide. The high mortality rate associated
with cancer is partially due to the lack of reliable early detection methods and/or inaccurate …

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

M Kato, R Natarajan - Nature Reviews Nephrology, 2019 - nature.com
The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside

M Ratti, A Lampis, M Ghidini, M Salati, MB Mirchev… - Targeted …, 2020 - Springer
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

MicroRNAs and complex diseases: from experimental results to computational models

X Chen, D Xie, Q Zhao, ZH You - Briefings in bioinformatics, 2019 - academic.oup.com
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …

Epigenetics and aging

S Pal, JK Tyler - Science advances, 2016 - science.org
Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

A 360 view of circular RNAs: From biogenesis to functions

JE Wilusz - Wiley Interdisciplinary Reviews: RNA, 2018 - Wiley Online Library
The first circular RNA (circRNA) was identified more than 40 years ago, but it was only
recently appreciated that circRNAs are common outputs of many eukaryotic protein‐coding …

Circulating cell-free nucleic acids: main characteristics and clinical application

M Szilágyi, O Pös, É Márton, G Buglyó… - International journal of …, 2020 - mdpi.com
Liquid biopsy recently became a very promising diagnostic method that has several
advantages over conventional invasive methods. Liquid biopsy may serve as a source of …

RNA sequencing and analysis

KR Kukurba, SB Montgomery - Cold Spring Harbor Protocols, 2015 - cshprotocols.cshlp.org
RNA sequencing (RNA-Seq) uses the capabilities of high-throughput sequencing methods
to provide insight into the transcriptome of a cell. Compared to previous Sanger sequencing …