Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

AKT/PKB serine threonine kinase, a critical signaling molecule promoting cell growth and
survival pathways, is frequently dysregulated in many cancers. Although …

Genomic findings underscore the heterogeneity of head and neck squamous cell carcinoma
(HNSCC). Identification of mutations that predict therapeutic response would be a major …

Head and neck squamous cell carcinoma (HNSCC) is one of the most morbid, mortal, and
genetically diverse malignancies. Although HNSCC is heterogeneous in nature, alterations …

Oral squamous cell carcinoma (OSCC) is the most common cancer of the oral cavity and
constitutes 95% of all cancers of this area. Men are affected twice as commonly as women …

Background Cetuximab, a monoclonal blocking antibody against the epidermal growth
factor receptor EGFR, has been approved for the treatment of squamous cell carcinomas of …

A growing subgroup of oropharyngeal cancers is initiated by infection with high-risk human
papillomaviruses (HPVs). In parallel to mounting epidemiological evidence, solid …

Oral squamous cell carcinoma (OSCC) of head and neck is associated with high morbidity
and mortality in both Western and Asian countries. Several risk factors for the development …

Targeted therapy against the epidermal growth factor receptor (EGFR) is one of the most
promising molecular therapeutics for head and neck squamous cell carcinoma (HNSCC) …

Oridonin, a bioactive diterpenoid purified from Rabdosia rubescens, has been shown to
possess anticancer capacity in several cancer types. However, its effects on oral squamous …