T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

CD8+ T cell responses are critical for anti-tumor immunity. While extensively profiled in the
tumor microenvironment, recent studies in mice identified responses in lymph nodes (LNs) …

CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …

PD-1+ TCF-1+ stem-like CD8 T cells act as critical resource cells for maintaining T cell
immunity in chronic viral infections and cancer. In addition, they provide the proliferative …

Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic
infection, developmental relationships and mechanisms underlying their fate decisions …

Glioblastomas are aggressive brain tumors that are largely immunotherapy resistant. This is
associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T …

Thirty years of foundational research investigating molecular and cellular mechanisms
promoting T cell exhaustion are now enabling rational design of T cell–based therapies for …

Prolonged lung pathology has been associated with COVID-19, yet the cellular and
molecular mechanisms behind this chronic inflammatory disease are poorly understood. In …

Dendritic cells (DCs) are a heterogeneous group of antigen-presenting innate immune cells
that regulate adaptive immunity, including against cancer. Therefore, understanding the …