The current role of liquid chromatography-tandem mass spectrometry in therapeutic drug monitoring of immunosuppressant and antiretroviral drugs
PJ Taylor, CH Tai, ME Franklin, PI Pillans - Clinical biochemistry, 2011 - Elsevier
Therapeutic drug monitoring of critical dose immunosuppressant drugs is established
clinical practice and there are similar good reasons to monitor antiretrovirals. The aim of this …
clinical practice and there are similar good reasons to monitor antiretrovirals. The aim of this …
Validation of a fast method for quantitative analysis of elvitegravir, raltegravir, maraviroc, etravirine, tenofovir, boceprevir and 10 other antiretroviral agents in human …
Z Djerada, C Feliu, C Tournois, D Vautier… - … of Pharmaceutical and …, 2013 - Elsevier
Therapeutic drug monitoring (TDM) of antiretrovirals requires accurate and precise analysis
of plasma drug concentrations. This work describes a simple, fast and sensitive UPLC …
of plasma drug concentrations. This work describes a simple, fast and sensitive UPLC …
Evaluation of the mean corpuscular volume of peripheral blood mononuclear cells of HIV patients by a coulter counter to determine intracellular drug concentrations
M Simiele, A D'Avolio, L Baietto… - Antimicrobial agents …, 2011 - Am Soc Microbiol
The mean corpuscular volume (MCV) of peripheral blood mononuclear cells (PBMCs) was
determined by Coulter Counter, and data were used to calculate the intracellular drug …
determined by Coulter Counter, and data were used to calculate the intracellular drug …
A HPLC–MS method for the simultaneous quantification of fourteen antiretroviral agents in peripheral blood mononuclear cell of HIV infected patients optimized using …
A D'Avolio, M Simiele, M Siccardi, L Baietto… - … of pharmaceutical and …, 2011 - Elsevier
A sensitive and accurate high performance liquid chromatography–mass spectrometric
(HPLC–MS) method for the intracellular determination of 14 antiretroviral drugs in peripheral …
(HPLC–MS) method for the intracellular determination of 14 antiretroviral drugs in peripheral …
Using dried blood spots to facilitate therapeutic drug monitoring of antiretroviral drugs in resource-poor regions
U Duthaler, B Berger, S Erb, M Battegay… - Journal of …, 2018 - academic.oup.com
Objectives We evaluated whether dried blood spots (DBS) are suitable to monitor combined
ART when samples are collected in rural Tanzania and transported over a long distance to a …
ART when samples are collected in rural Tanzania and transported over a long distance to a …
UPLC–MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues
Animal pharmacokinetic and tissue distribution assays of antiretroviral therapeutic drugs
require accurate drug quantification in biological fluids and tissues. Here we report a simple …
require accurate drug quantification in biological fluids and tissues. Here we report a simple …
Intracellular and plasma steady‐state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre‐treated HIV‐infected patients
R Ter Heine, JW Mulder, ECM Van Gorp… - British journal of …, 2010 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• The combination of raltegravir,
etravirine and ritonavir boosted darunavir is a potent antiretroviral regimen for patients who …
etravirine and ritonavir boosted darunavir is a potent antiretroviral regimen for patients who …
[HTML][HTML] Validation of a UHPLC-MS/MS method to quantify twelve antiretroviral drugs within peripheral blood mononuclear cells from people living with HIV
A De Nicolò, A Ianniello, M Ferrara, V Avataneo… - Pharmaceuticals, 2020 - mdpi.com
Recently, anti-HIV treatment has achieved high efficacy and tolerability. Nevertheless, few
data are available about the intracellular penetration of antiretrovirals, partly due to the …
data are available about the intracellular penetration of antiretrovirals, partly due to the …
Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC‐MS/MS
T Mishra, PS Shrivastav - The Scientific World Journal, 2014 - Wiley Online Library
Objectives. HIV protease inhibitors are used in the treatment of patients suffering from AIDS
and they act at the final stage of viral replication by interfering with the HIV protease enzyme …
and they act at the final stage of viral replication by interfering with the HIV protease enzyme …
Electrochemical evaluation and determination of antiretroviral drug fosamprenavir using boron-doped diamond and glassy carbon electrodes
M Gumustas, SA Ozkan - Analytical and bioanalytical chemistry, 2010 - Springer
Fosamprenavir is a pro-drug of the antiretroviral protease inhibitor amprenavir and is
oxidizable at solid electrodes. The anodic oxidation behavior of fosamprenavir was …
oxidizable at solid electrodes. The anodic oxidation behavior of fosamprenavir was …