WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Excessive trabeculation, often referred to as “noncompacted” myocardium, has been
described at all ages, from the fetus to the adult. Current evidence for myocardial …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes,
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

The cardiac conduction system (CCS) consists of distinctive components that initiate and
conduct the electrical impulse required for the coordinated contraction of the cardiac …

The heart, an ancient organ and the first to form and function during embryogenesis, evolved
by the addition of new structures and functions to a primitive pump. Heart development is …

Background: Left ventricular noncompaction cardiomyopathy (LVNC) was discovered half a
century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Drugs targeting atrial‐specific ion channels, Kv1. 5 or Kir3. 1/3.4, are being developed as
new therapeutic strategies for atrial fibrillation. However, current preclinical studies carried …