Notwithstanding the ongoing debate on their full potential in health and disease, there is
general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 …

Over the last two decades, activity‐based protein profiling (ABPP) has been established as a
tremendously useful proteomic tool for measuring the activity of proteins in their cellular …

Ferroptosis, an iron‐dependent cell death characterized by lethal lipid peroxidation, is
involved in chronic obstructive pulmonary disease (COPD) pathogenesis. Therefore …

Emerging evidence points to the intertwining framework of inflammation and oxidative stress
in various ailments. We speculate on the potential impact of the magic shotgun approach in …

Highlights•Activity-based probes are versatile tools to study protein function and biological
context.•Selective and non-selective ABPs are used for target evaluation.•Proteomic …

Various mechanisms for regulated cell death include the formation of oxidative mediators
such as lipid peroxides and nitric oxide (NO). In this respect, 15-lipoxygenase-1 (15-LOX-1) …

Retinaldehyde dehydrogenases belong to a superfamily of enzymes that regulate cell
differentiation and are responsible for detoxification of anticancer drugs. Chemical tools and …

TMS-substituted alkynes are versatile building blocks in organic synthesis. Traditional
synthesis involves alkyne deprotonation and the reaction with TMSCl. Recently, TMS …

The site‐selective modification of complex biomolecules by transition metal‐catalysis is
highly warranted, but often thwarted by the presence of Lewis basic functional groups. This …

Abstract Human 15‐lipoxygenase‐1 (15‐LOX‐1) is a key enzyme that possesses an
important role in (neuro) inflammatory diseases. The pocket of the enzyme plays the role of a …