Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor
microenvironment (TME), where it can promote tumor progression or tumor suppression …

While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …

Cancers are able to grow by subverting immune suppressive pathways, to prevent the
malignant cells as being recognized as dangerous or foreign. This mechanism prevents the …

Inflammatory conditions are associated with the extracellular release of nucleotides,
particularly ATP. In the extracellular compartment, ATP predominantly functions as a …

The extracellular nucleoside adenosine reduces tissue inflammation and is generated by
irreversible dephosphorylation of adenosine monophosphate (AMP) mediated by the …

Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a
wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney …

Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

Receptors for ATP and ADP and adenosine exert various effects. ATP and ADP signaling is
mainly proinflammatory, and adenosine signaling is mainly antiinflammatory. Receptors for …

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars,
adenosine, and adenine base participate in the “purinergic signalling” pathway, an …

Stimulation of almost all mammalian cell types leads to the release of cellular ATP and
autocrine feedback through a diverse array of purinergic receptors. Depending on the types …