Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …

The poor predictability of human liver toxicity is still causing high attrition rates of drug
candidates in the pharmaceutical industry at the non-clinical, clinical, and post-marketing …

The liver is the largest internal organ in the human body with largest mass of glandular
tissue. Modeling the liver has been challenging due to its variety of major functions …

Drug‐induced liver injury (DILI) is a leading cause of therapy failure in the clinic and also
contributes much to acute liver failure cases. Investigations of predictive sensitivity in animal …

Simple Summary Various 3D in vitro tumor models are rapidly advancing cancer research.
Unlike animal models, they can be produced quickly and are amenable to high-throughput …

Strong research and development barriers and steep patent cliffs have put forward higher
and higher requirements in the field of pharmaceutical analysis, such as analysis efficiency …

Nutraceuticals in the food sector open doors to the future of “nanoscience” technology that
has gained much importance. Nanotechnology has established a new perspective by …

The pressing demand for a creative method to effectively model human drug responses in
preclinical research has prompted the advancement of organ-on-a-chip (OoC) systems …

As many consider organ on a chip for better in vitro models, it is timely to extract quantitative
data from the literature to compare responses of cells under flow in chips to corresponding …

The pre-clinical trials in the drug discovery timeline involve an immense amount of time and
money to elucidate the drug responses precisely. Cell culture techniques have been utilized …